A single-cell mathematical model of SARS-CoV-2 induced pyroptosis and the effects of anti-inflammatory intervention

Pyroptosis is an inflammatory mode of cell death that can contribute to the cytokine storm associated with severe cases coronavirus disease 2019 (COVID-19). The formation NLRP3 inflammasome central pyroptosis, which may be induced by acute respiratory syndrome 2 (SARS-CoV-2). Inflammasome formation, and extension inhibited certain anti-inflammatory drugs. In this study, we present a single-cell mathematical model captures inflammasome, pyroptotic responses intervention hinder inflammasome. formulated in terms system ordinary differential equations (ODEs) describe dynamics key biological components involved pyroptosis. Our results demonstrate drug delay thus alter from (pyroptosis) non-inflammatory (e.g., apoptosis). implemented within SARS-CoV-2 tissue simulator, collaboration multidisciplinary coalition investigating host-dynamics COVID-19. paper, additionally provide overview simulator highlight effects pyroptosis on cellular level.